Microbiota translocation following intestinal barrier disruption promotes Mincle-mediated training of myeloid progenitors in the bone marrow
Iñaki Robles‐Vera, Aitor Jarit-Cabanillas, Paola Brandi, María Martínez‐López, Sarai Martínez-Cano, Manuel Rodrigo-Tapias, Marcos Femenía-Muiña, Ana Redondo‐Urzainqui, Vanesa Nuñez, Cristina González‐Correa, Javier Moleón, Juan Duarte, Laura Conejero, Pablo Mata-Martínez, Carmen M. Diez‐Rivero, Marta Bergón-Gutiérrez, Ivan Fernández-López, Manuel J. Gómez, Ana Quintas, Ana Dopazo, Fátima Sánchez‐Cabo, Esther Pariente, Carlos del Fresno, José Luis Subiza, Salvador Iborra, David Sancho
Abstract
mice showed impaired TI upon E. faecalis administration and reduced pathology following DSS treatment. Thus, Mincle sensing of E. faecalis induces TI that may have long-term effects on pathologies associated with increased gut permeability.
Topics & Concepts
Chromosomal translocationBiologyBone marrowMyeloidProgenitor cellCell biologyProgenitorHaematopoiesisMyeloid cellsCancer researchImmunologyStem cellGeneticsGeneImmune responses and vaccinationsImmune cells in cancerGut microbiota and health