Detection of breastmilk antibodies targeting SARS-CoV-2 nucleocapsid, spike and receptor-binding-domain antigens
David M. Favara, M. L. Ceron-Gutierrez, George Carnell, Jonathan L. Heeney, Pippa Corrie, Rainer Döffinger
Abstract
A 40-year-old female was found to have strongly neutralizing SARS-CoV-2 breastmilk IgA and IgG antibodies reactive against multiple SARS-CoV-2 antigens at 2.5 months after documented infection with SARS-CoV-2. At 6.5 months following the infection, she remained positive for breastmilk and serum SARS-CoV-2 neutralizing antibodies. Holder breast milk pasteurization did not diminish SARS-CoV-2 antibody titres but it reduced its neutralizing capacity, while serum heat inactivation had no negative effect on SARS-CoV-2 serum antibody levels and neutralizing capacity. Current data on SARS-CoV-2 and breastmilk are reviewed.
Topics & Concepts
AntibodyVirologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)AntigenMedicineNeutralizing antibodyImmunologyCoronavirus disease 2019 (COVID-19)Internal medicineDiseaseInfectious disease (medical specialty)COVID-19 Impact on ReproductionSARS-CoV-2 and COVID-19 ResearchDermatological and COVID-19 studies