Recent clinical advances in fibroblast activation protein targeted radioligand therapy for solid tumors
Xiaolong Wu, Yu Wang, Yingchun Li, Wenli Hu
Abstract
Fibroblast activation protein (FAP) is a type II transmembrane serine protease predominantly expressed by cancer-associated fibroblasts (CAFs) in more than 90% of epithelial malignancies. The advent of FAP inhibitor (FAPI)-based positron emission tomography (PET) imaging has established FAP as a promising pan-tumor target for radioligand therapy (RLT). This review summarizes the current clinical landscape of FAP-targeted RLT in solid tumors, while also discussing existing challenges and future directions in this rapidly evolving field.
Topics & Concepts
Fibroblast activation protein, alphaRadioligandSerine proteaseCancer researchFibroblastPositron emission tomographyChemistryTransmembrane proteinMedicineProteaseTargeted therapySerineCell biologyLigand (biochemistry)Molecular biologyPathologyFusion proteinReceptorOligopeptidePet imagingPeptidase Inhibition and AnalysisConnective tissue disorders researchCardiac Fibrosis and Remodeling