Effect of glycocalyx-targeted therapy on vascular function in older adults: a randomized controlled trial
Colin J. Gimblet, Jackson W. Ernst, Blair Bell, Kyle D. Bos, Amy K. Stroud, Linder Wendt, Anthony J. Donato, Diana Jalal, Gary L. Pierce
Abstract
Endothelial glycocalyx thickness and vascular endothelial function decline with advancing age. Endocalyx Pro is a glycocalyx-targeted therapy that may improve endothelial glycocalyx thickness and vascular endothelial function in older adults. This study demonstrated that 12-wk Endocalyx Pro supplementation did not improve overall endothelial glycocalyx thickness or flow-mediated dilation in older adults; however, Endocalyx Pro did increase capillary glycocalyx thickness in individuals not taking antihypertensive medication and improve flow-mediated dilation normalized to the shear stimulus.
Topics & Concepts
Randomized controlled trialMedicineGlycocalyxInternal medicineImmunologyBlood Pressure and Hypertension StudiesRenal function and acid-base balanceTrauma, Hemostasis, Coagulopathy, Resuscitation