Construction of sulfur-containing compounds with anti-cancer stem cell activity using thioacrolein derived from garlic based on nature-inspired scaffolds
Taichi Yoneda, Naoto Kojima, Takahiro Μatsumoto, Daisuke Imahori, Tomoe Ohta, Tatsusada Yoshida, Tetsushi Watanabe, Hisashi Matsuda, Seikou Nakamura
Abstract
We reported for the first time that thioacroleinproduced by allicin, a major component in garlic, undergoes the regioselective sequential double Diels–Alder reaction.
Topics & Concepts
Organosulfur compoundsChemistryAllicinRegioselectivitySilyl etherCombinatorial chemistrySulfurEtherEnolDieneOrganic chemistrySilylationCatalysisNatural rubberGarlic and Onion StudiesFungal Plant Pathogen ControlPhytochemical compounds biological activities