Repurposing an Antiviral Drug against SARS‐CoV‐2 Main Protease
Arighna Sarkar, Kalyaneswar Mandal
Abstract
This article highlights recent pioneering work by Günther et al. towards the discovery of potential repurposed antiviral compounds (peptidomimetic and non-peptidic) against the SARS-CoV-2 main protease (Mpro). The antiviral activity of the most potent drugs is discussed along with their binding mode to Mpro as observed through X-ray crystallographic screening.
Topics & Concepts
RepurposingSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakVirologyPublishingChemistryDrug repositioningDrugMedicinePharmacologyBiologyPolitical scienceInfectious disease (medical specialty)EcologyOutbreakDiseaseLawPathologyComputational Drug Discovery MethodsSynthesis and biological activityVitamin C and Antioxidants Research