CircMRE11A_013 binds to UBXN1 and integrates ATM activation enhancing lens epithelial cells senescence in age-related cataract
Junliang Liu, Jinling Zhang, Guowei Zhang, Tianqiu Zhou, Xi Zou, Huaijin Guan, Yong Wang
Abstract
, recombinant adeno-associated virus vectors (rAAV-2) virions of circMRE11A (circMRE11A-AAV2) was injected to Institute of Cancer Research mouse vitreous cavity. The circMRE11A-AAV2 could express in mouse lens at 4 weeks. The LECs aging and opacity lens were observed at 8 weeks after the injection. Together, our findings reveal a previously unidentified role of circMRE11A interacting with UBXN1 in enhancing ATM activity and inhibiting LECs cell-cycle in ARCC formation. The findings might give us a better understanding of ARC pathology and provide a novel and more effective therapeutic approaches for ARC treatment.
Topics & Concepts
SenescenceCell biologyLens (geology)Cellular senescenceChemistryCancer researchBiologyBiochemistryGenePhenotypePaleontologyCircular RNAs in diseasesCardiovascular, Neuropeptides, and Oxidative Stress ResearchMicroRNA in disease regulation