Cp*Co<sup>III</sup>-Catalyzed C(7)–H Bond Annulation of Indolines with Alkynes
Rajib Mandal, Bholanath Garai, Basker Sundararaju
Abstract
An efficient protocol for the synthesis of biologically essential pyrroloquinolinones has been developed under Cp*CoIII catalysis, which involves a cascade reaction of C(7)–H alkenylation with alkynes followed by nucleophilic addition. A wide variety of internal alkynes including enyne, diyne, and ynamide and more challenging terminal alkynes were successfully employed for the annulation in good to excellent yield with high regioselectivity.
Topics & Concepts
ChemistryAnnulationRegioselectivityYield (engineering)CatalysisEnyneNucleophileCombinatorial chemistryMedicinal chemistryTriple bondNucleophilic additionAlkyneOrganic chemistryDouble bondMaterials scienceMetallurgyCatalytic C–H Functionalization MethodsCatalytic Alkyne ReactionsOxidative Organic Chemistry Reactions