FABP5 suppresses colorectal cancer progression via mTOR-mediated autophagy by decreasing FASN expression
Mujie Ye, Chunhua Hu, Tiaotiao Chen, Ping Yu, Jinhao Chen, Feiyu Lu, Lin Xu, Yuan Zhong, Lijun Yan, Jingbao Kan, Jian’an Bai, Xiaolin Li, Ye Tian, Qiyun Tang
Abstract
axis in tumor progression and uncover a potential mechanism linking lipid metabolism to development of CRC, providing novel therapeutic targets for future interventions.
Topics & Concepts
Fatty acid synthasePI3K/AKT/mTOR pathwayAutophagyFatty acid-binding proteinCancer researchLipid metabolismCancerColorectal cancerBiologyChemistryCell biologySignal transductionBiochemistryApoptosisGeneGeneticsPeroxisome Proliferator-Activated ReceptorsCancer, Lipids, and MetabolismCancer-related gene regulation