The ethylmalonyl-CoA pathway for methane-based biorefineries: a case study of using <i>Methylosinus trichosporium</i> OB3b, an alpha-proteobacterial methanotroph, for producing 2-hydroxyisobutyric acid and 1,3-butanediol from methane
Dung Hoang Anh, Nguyễn Thị Hoài Thu, Eun Yeol Lee
Abstract
Through genome-scale metabolic model simulations and transcriptomic analysis the ethylmalonyl-CoA pathway of an alpha-proteobacteria, Methylosinus trichosporium OB3b, was systematically assessed and exploited to produce 2-hydroxybutiric acid and 1,3-butanediol from methane.
Topics & Concepts
MethanotrophChemistryMethaneBiochemistryAnaerobic oxidation of methaneOrganic chemistryMicrobial Metabolic Engineering and BioproductionBiofuel production and bioconversionMicrobial metabolism and enzyme function