A multifunctional nanoplatform delivering carbon monoxide and a cysteine protease inhibitor to mitochondria under NIR light shows enhanced synergistic anticancer efficacy
Qi Tang, Jing Liu, Jing Liu, Chengbin Wang, Lu An, Hailin Zhang, Yi Wang, Bing Ren, Shiping Yang, Jin‐Gang Liu, Jin‐Gang Liu
Abstract
anticancer efficacy. In addition, nanoplatform (1) has good biocompatibility and did not exert any toxic side effects on mice during the period of treatment. The targeted subcellular mitochondrial co-delivery of CO and the cysteine protease inhibitor may provide new insights into CO and enzyme inhibitor combined therapies for cancer treatment.
Topics & Concepts
MitochondrionChemistryCysteine proteaseCysteineIn vivoBiophysicsCarbon monoxideIn vitroBiochemistryEnzymeCombinatorial chemistryBiologyBiotechnologyCatalysisNanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsCarbon and Quantum Dots Applications