Synthesis of novel dual target inhibitors of PARP and HSP90 and their antitumor activities
Shanshan Lin, Lingyu Zhang, Xiao Zhang, Zelei Yu, Xiuwang Huang, Jianhua Xu, Yang Liu, Limin Chen, Lixian Wu
Topics & Concepts
OlaparibPoly ADP ribose polymeraseChemistryPARP inhibitorHsp90EnzymePolymeraseCurcuminPharmacologyCancer researchBiochemistryHeat shock proteinBiologyGenePARP inhibition in cancer therapyToxin Mechanisms and ImmunotoxinsCell death mechanisms and regulation