Ameliorative role of dietary activated carbon against ochratoxin-A induced oxidative damage, suppressed performance and toxicological effects
Sheraz Ahmed Bhatti, Muhammad Zargham Khan, Muhammad Kashif Saleemi, Zahoor Ul Hassan, Ahrar Khan
Abstract
The present study reports that dietary addition of 2.5, 5.0, 10.0 g/kg activated charcoal (AC) in broiler feed contaminated with 0.15, 0.3 and 1.0 mg/kg ochratoxin A (OTA) showed a partial reduction in intensity of mycotoxins induced toxic effects; particularly against those induced at lower doses of toxin (0.15 and 0.3 mg/kg). The protection by AC was absent against 1.0 mg/kg OTA-mediated toxicities. Moreover, AC at 10 g/kg feed also imparted toxicological effects in broiler chicken. It can be concluded that AC possess limited adsorptive potential against OTA and increasing the dose of AC may be detrimental for animal health.
Topics & Concepts
Ochratoxin ABroilerMycotoxinActivated charcoalChemistryToxinOchratoxinOxidative stressFood scienceOxidative damageActivated carbonBiochemistryOrganic chemistryAdsorptionMycotoxins in Agriculture and FoodPesticide Residue Analysis and SafetyWheat and Barley Genetics and Pathology