Effects of Sepsis on Immune Response, Microbiome and Oxidative Metabolism in Preterm Infants
Anna Parra‐Llorca, Alejandro Pinilla‐González, Laura Torrejón‐Rodríguez, Inmaculada Lara‐Cantón, Julia Kuligowski, María Carmen Collado, María Gormáz, Marta Aguar, Máximo Vento, Eva Serna, María Cernada
Abstract
This is a narrative review about the mechanisms involved in bacterial sepsis in preterm infants, which is an illness with a high incidence, morbidity, and mortality. The role of the innate immune response and its relationship with oxidative stress in the pathogenesis are described as well as their potential implementation as early biomarkers. Moreover, we address the impact that all the mechanisms triggered by sepsis have on the dysbiosis and the changes on neonatal microbiota.
Topics & Concepts
SepsisMicrobiomeImmune systemImmunologyOxidative stressDysbiosisPathogenesisMedicineNeonatal sepsisIncidence (geometry)Oxidative metabolismNarrative reviewBioinformaticsIntensive care medicineBiologyMetabolismGut floraInternal medicinePhysicsOpticsNeonatal and Maternal InfectionsInfant Nutrition and HealthNeonatal Respiratory Health Research