The role of hypoxia-inducible factor 1 alpha (HIF-1α) modulation in heavy metal toxicity
Michael Aschner, Anatoly V. Skalny, Rongzhu Lu, Abel Santamarı́a, Ji‐Chang Zhou, Tao Ke, M. Yu. Karganov, Aristides Tsatsakis, Kirill S. Golokhvast, Aaron B. Bowman, Alexey A. Tinkov
Topics & Concepts
Signal transductionCell biologyPI3K/AKT/mTOR pathwayHypoxia-inducible factorsHypoxia (environmental)Cellular adaptationProtein kinase BMAPK/ERK pathwayAngiogenesisReactive oxygen speciesChemistryMetal toxicityBiologyCancer researchToxicityBiochemistryOxygenOrganic chemistryGeneCancer, Hypoxia, and MetabolismMesenchymal stem cell researchHydrogen's biological and therapeutic effects