Myoferlin targeting triggers mitophagy and primes ferroptosis in pancreatic cancer cells
Gilles Rademaker, Yasmine Boumahd, Raphaël Peiffer, Sandy Anania, Tom Wissocq, Maude A. Liegeois, Géraldine Luis, Nor Eddine Sounni, Ferman Agirman, Naïma Maloujahmoum, Pascal De Tullio, Marc Thiry, Akeila Bellahcène, Vincent Castronovo, Olivier Peulen
Abstract
cystine/glutamate transporter and GPX-4. Mitophagy inhibitor Mdivi1 and iron chelators inhibited the myoferlin-related ROS production and restored cell growth. Additionally, we reported a synergic effect between ferroptosis inducers, erastin and RSL3, and WJ460.
Topics & Concepts
MitophagyProgrammed cell deathMitochondrionCell biologyCancer cellBiologyApoptosisCancer researchMitochondrial ROSPancreatic cancerReactive oxygen speciesChemistryCancerAutophagyBiochemistryGeneticsFerroptosis and cancer prognosisRNA modifications and cancerCancer-related molecular mechanisms research