Binuclear Complexes of Cu(II) and Mg(II) with 2-Furancarboxylic Acid: Synthesis, Structure, EPR Spectroscopy, and Results of In Vitro Biological Activity against Mycolicibacterium Smegmatis and SCOV3
Irina А. Lutsenko, М. Е. Никифорова, К. А. Кошенскова, Mikhail A. Kiskin, Yulia V. Nelyubina, Petr V. Primakov, Matvey V. Fedin, O. B. Becker, Victoria О. Shender, Irina K. Malyants, И.Л. Еременко
Abstract
Using the reactions of copper(II) acetate magnesium(II) oxide with 2-furancarboxylic acid (HFur), compounds with chemical compositions [Cu2(Fur)4(MeCN)2] (I) and [Mg2(Fur)4(H2O)5]∙ MeCN∙H2O (II) are synthesized. According to the X-ray diffraction data (CIF files CCDC nos. 2085817 (I) and 2085818 (II)), both complexes have a binuclear structure. The metal core of I correspond to the tetracarboxylate bridged {Cu2(μ-Fur)4} complex, the coordination number of the copper atom in which is 5 (CuNO4); in II, the metal atoms are linked by two carboxylate groups and a water molecule, and the coordination environment of the metal centers is completed to the polyhedron (MgO6) by oxygen atoms of the Fur– anions and water molecules. According to EPR spectroscopy data, exchange-coupled copper(II) dimers with a substantial zero-field splitting are observed in I. For I and II, antibacterial activity against the nonpathogenic strain of M. smegmatis, and cytotoxicity against human ovarian adenocarcinoma cells SCOV3 and normal human fibroblast cells of the HDF line have been determined.