Development and validation of a method for quantification of human insulin and its synthetic analogues in plasma and post-mortem sera by LC-MS/HRMS
Charline Bottinelli, Raul Nicoli, Fabien Bévalot, Nathalie Cartiser, Christelle Roger, Karim Chikh, Tiia Kuuranne, Laurent Fanton, Jérôme Guitton
Topics & Concepts
ChemistryChromatographyProtein precipitationIon suppression in liquid chromatography–mass spectrometryDetection limitSolid phase extractionExtraction (chemistry)Matrix (chemical analysis)Mass spectrometryLiquid chromatography–mass spectrometryForensic Toxicology and Drug AnalysisHormonal and reproductive studiesMass Spectrometry Techniques and Applications