Cu(OTf)<sub>2</sub>-Catalyzed Intramolecular Radical Cascade Reactions for the Diversity-Oriented Synthesis of Quinoline-Annulated Polyheterocyclic Frameworks
Shuo Yuan, Jingya Zhang, Danqing Zhang, Donghui Wei, Jia-Hui Zuo, Jian Song, Bin Yu, Hong‐Min Liu
Abstract
-catalyzed intramolecular radical cascade reactions that enable the diversity-oriented synthesis of quinoline-annulated polyheterocyclic compounds (7 unique scaffolds, 66 examples) in an efficient manner. This work demonstrates an alternative route to access the natural product- and druglike compound collection with high levels of structural diversity and novelty.
Topics & Concepts
ChemistryIntramolecular forceQuinolineCombinatorial chemistryCatalysisNatural productDrug discoveryChemical spaceCascadeStereochemistryOrganic chemistryChromatographyBiochemistryCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques