Upregulation of TRIM16 mitigates doxorubicin-induced cardiotoxicity by modulating TAK1 and YAP/Nrf2 pathways in mice
Xinyu Guo, Mengqing Liu, Bing Han, Y. Zheng, Kaina Zhang, Gaowa Bao, Chenying Gao, Hongwen Shi, Qiang Sun, Zhenghang Zhao
Topics & Concepts
CardiotoxicityDoxorubicinDownregulation and upregulationOxidative stressInflammationGene knockdownUbiquitin ligaseMedicineApoptosisCancer researchPharmacologyFibrosisUbiquitinChemistryCell biologyInternal medicineBiologyToxicityChemotherapyBiochemistryGeneCardiovascular Effects of ExerciseChemotherapy-induced cardiotoxicity and mitigationPARP inhibition in cancer therapy