Characterization of a putative sensory [FeFe]-hydrogenase provides new insight into the role of the active site architecture
Henrik Land, Alina Sekretareva, Ping Huang, Holly J. Redman, Brigitta Németh, Nakia Polidori, Lívia S. Mészáros, Moritz Senger, Sven T. Stripp, Gustav Berggren
Abstract
interconversion, and unusual reactivity towards known hydrogenase inhibitors. These properties are related to differences in active site architecture between the M2e [FeFe]-hydrogenase and "prototypical" [FeFe]-hydrogenases. Thus, this study provides new insight into the role of this subclass in hydrogen metabolism and the influence of the active site pocket on the chemistry of the H-cluster.
Topics & Concepts
HydrogenaseActive siteChemistryCluster (spacecraft)Characterization (materials science)Sensory systemCatalysisStereochemistryCombinatorial chemistryNanotechnologyBiochemistryMaterials scienceBiologyNeuroscienceComputer scienceProgramming languageMetalloenzymes and iron-sulfur proteinsElectrocatalysts for Energy ConversionAdvanced battery technologies research