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Regulation of Keap-1/Nrf2/AKT and iNOS/NF-κB/TLR4 signals by apocynin abrogated methotrexate-induced testicular toxicity: Mechanistic insights and computational pharmacological analysis

Ahmed M. Sayed, Emad H. M. Hassanein, Fares E.M. Ali, Zainab Omar, Eman K. Rashwan, Zuhair M. Mohammedsaleh, Omnia A. M. Abd El‐Ghafar

2021Life Sciences39 citationsDOI

Topics & Concepts

ApocyninPharmacologyToxicityProtein kinase BChemistryTLR4MedicineSignal transductionBiochemistryInternal medicineOxidative stressNADPH oxidaseChemotherapy-induced organ toxicity mitigationRetinoids in leukemia and cellular processesDrug-Induced Hepatotoxicity and Protection
Regulation of Keap-1/Nrf2/AKT and iNOS/NF-κB/TLR4 signals by apocynin abrogated methotrexate-induced testicular toxicity: Mechanistic insights and computational pharmacological analysis | Litcius