Insights into the binding and covalent inhibition mechanism of PF-07321332 to SARS-CoV-2 M <sup>pro</sup>
Sơn Tùng Ngô, Trung Hai Nguyen, Nguyễn Thanh Tùng, Binh Khanh
Abstract
The catalytic triad Cys145–His41–Asp187 of SARS-CoV-2 M pro plays an important role in the activation of the PF-07321332 covalent inhibitor.
Topics & Concepts
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Covalent bondCoronavirus disease 2019 (COVID-19)ProteaseMechanism (biology)Severe acute respiratory syndrome coronavirus2019-20 coronavirus outbreakVirologyCoronavirusPandemicViral replicationChemistryEnzymeStereochemistryMedicineBiochemistryVirusPhysicsOutbreakInternal medicineOrganic chemistryDiseaseQuantum mechanicsInfectious disease (medical specialty)Computational Drug Discovery MethodsSynthesis and biological activityBioactive Compounds and Antitumor Agents