An efficient and facile strategy for trifluoromethylation and perfluoroalkylation of isoquinolines and heteroarenes
Yang Pan, Jiangtao Li, Zhefeng Li, Feng Huang, Xiaofeng Ma, Wei Jiao, Huawu Shao
Abstract
An effective and regioselective strategy for trifluoromethylation and perfluoroalkylation of isoquinolines and heteroarenes was developed. By combination of TMSCnF2n+1 (n = 1, 2, 3) with PIFA, the method achieved the corresponding perfluoroalkylated products with broad functional group tolerance.
Topics & Concepts
TrifluoromethylationChemistryCombinatorial chemistryOrganic chemistryTrifluoromethylAlkylFluorine in Organic ChemistryCyclopropane Reaction MechanismsInorganic Fluorides and Related Compounds