HIF-1-mediated macrophage metabolic reprogramming promotes AKI to CKD transition
Hong Ding, Yan Zhou, Ren-He Zhu, Shu‐Hong Yu, Aiqing Zhang, Hong Liu, Jialing Ji, Zuo‐Lin Li
Abstract
. Taken together, our studies provide a novel paradigm in which pro-inflammatory macrophage orchestrates renal maladaptive repair, contributing to the AKI to CKD transition. Blockade of NF-κB-HIF-1 signaling-mediated macrophage metabolic reprogramming may provide attractive strategy for pharmacologic therapy of the AKI to CKD transition.
Topics & Concepts
Kidney diseaseMacrophageAcute kidney injuryFibrosisReprogrammingMedicineCancer researchKidneyNephrologyGlycolysisBlockadeDownregulation and upregulationCellInternal medicineMyeloid cellsPathologyEpithelial–mesenchymal transitionLipid metabolismCell biologyM2 MacrophageEndocrinologyKnockout mouseBiologyChemistryImmunologyUrinary systemMacrophage polarizationPancreatic function and diabetesCancer, Hypoxia, and MetabolismMetabolism and Genetic Disorders