Cardiac reverse remodeling in a mouse model with many phenotypical features of heart failure with preserved ejection fraction: effects of modifying lifestyle
Mohamed Lamine Aidara, Élisabeth Walsh‐Wilkinson, Sara-Ève Thibodeau, Emylie-Ann Labbé, Audrey Morin-Grandmont, Geneviève Gagnon, Dominique K. Boudreau, Marie Arsenault, Yohan Bossé, Jacques Couët
Abstract
Using a two-hit murine model of heart failure with preserved ejection fraction (HfpEF), combining elevated blood pressure, obesity, and exercise intolerance in male and female animals, we showed that correction of hypertension, normalization of the diet, and introduction of voluntary exercise could help reverse the remodeling of the left ventricle and double exercise capacity. We also identify genes that escape normalization after myocardial recovery and differences between males' and females' responses to stress and recovery.
Topics & Concepts
Ejection fractionInternal medicineHeart failureVentricular remodelingMedicineHeart failure with preserved ejection fractionCardiologyConcentric hypertrophyAngiotensin IIFibrosisMuscle hypertrophyEndocrinologyDiastoleBlood pressureCardiovascular Function and Risk FactorsCardiomyopathy and Myosin StudiesCardiac Fibrosis and Remodeling