Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling
Elliott D. Bayle, Fredrik Svensson, Benjamin N. Atkinson, David Steadman, Nicky J. Willis, Hannah L. Woodward, Paul J. Whiting, Jean‐Paul Vincent, Paul V. Fish
Abstract
), which are complementary chemical tools for exploring the role of Notum in Wnt signaling.
Topics & Concepts
Wnt signaling pathwayDruggabilityComputational biologyRegulatorSignal transductionBiologyCell biologyGeneticsGeneWnt/β-catenin signaling in development and cancerCholinesterase and Neurodegenerative DiseasesCancer-related gene regulation