Genomic Surveillance and Improved Molecular Typing of Bordetella pertussis Using wgMLST
Michael R. Weigand, Yanhui Peng, Hannes Pouseele, Dane A. Kania, Katherine E. Bowden, Margaret M. Williams, M. Lucia Tondella
Abstract
Multilocus sequence typing (MLST) provides allele-based characterization of bacterial pathogens in a standardized framework. However, classical MLST schemes for Bordetella pertussis , the causative agent of whooping cough, seldom reveal diversity among the small number of gene targets and thereby fail to delineate population structure.
Topics & Concepts
Multilocus sequence typingBiologyBordetella pertussisTypingPopulationGenomeWhooping coughGeneticsGenotypeVirologyGeneMedicineVaccinationBacteriaEnvironmental healthBacterial Infections and VaccinesInfective Endocarditis Diagnosis and ManagementPneumonia and Respiratory Infections