Downregulation of metabotropic glutamate receptor 5 alleviates central sensitization by activating autophagy via inhibiting mTOR pathway in a rat model of chronic migraine
Yingying Niu, Xiaoxu Zeng, Guangcheng Qin, Dunke Zhang, Jiying Zhou, Lixue Chen
Topics & Concepts
Metabotropic glutamate receptor 5Downregulation and upregulationSensitizationAutophagyPI3K/AKT/mTOR pathwayMetabotropic glutamate receptorCalcitonin gene-related peptideGlutamate receptorAllodyniaChemistryMedicinePharmacologyHyperalgesiaEndocrinologyInternal medicineReceptorSignal transductionNociceptionNeuropeptideImmunologyBiochemistryGeneApoptosisNeuroscience of respiration and sleepNeuroscience and Neuropharmacology ResearchBiochemical effects in animals