Conformational transformation of activator strand directly regulates CRISPR/Cas12a system activity for live cell sensing of multiple biomolecules
Qingnan Li, Dongxia Wang, Zhi‐Qi Dai, Shun-Li Wu, Gui‐Mei Han, Sha Lu, Li‐Na Zhu, Hongxin Jiang, De‐Ming Kong
Topics & Concepts
BiomoleculeCRISPRTransformation (genetics)ChemistryActivator (genetics)BiophysicsCellCell biologyNanotechnologyComputational biologyBiologyBiochemistryMaterials scienceReceptorGeneCRISPR and Genetic EngineeringAdvanced biosensing and bioanalysis techniquesRNA and protein synthesis mechanisms