Behind the Scenes of TOPCAT — Bending to Inform
Marc A. Pfeffer, Brian Claggett
Abstract
Behind the Scenes of TOPCAT - Bending to InformWhen investigators in a 2013 RCT received their unblinded results, the data forced them to make a difficult decision - do they stay within conventional guidelines for data analysis or forge a new path? This Clinical Trial Case Study tells the story of how they dealt with the data dilemma for a heart failure treatment that affects millions of people.
Topics & Concepts
DilemmaRandomized controlled trialPsychologyMedicineSurgeryEpistemologyPhilosophyHeart Failure Treatment and ManagementCardiovascular Function and Risk FactorsHealth Systems, Economic Evaluations, Quality of Life