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Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of hepatic encephalopathy via induction of Nrf2/HO-1 and mitigation of NF-κB/MAPK signaling pathways

Heba M. A. Khalil, Hesham A. Eliwa, Riham A. El‐Shiekh, Asmaa K. Al‐Mokaddem, Marwa Hassan, Azza M. Tawfek, Walaa H. El-Maadawy

2021Journal of Ethnopharmacology83 citationsDOI

Topics & Concepts

Withania somniferaThioacetamidePharmacologyHepatoprotectionNitric oxide synthaseElevated plus mazeOxidative stressHepatic encephalopathyMalondialdehydeMorris water navigation taskOpen fieldMedicineChemistryGlutathioneBiochemistryNitric oxideHippocampusInternal medicineCirrhosisPathologyEnzymePsychiatryAlternative medicineAnxietyPhytochemicals and Medicinal PlantsLiver Disease and TransplantationDrug-Induced Hepatotoxicity and Protection
Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of hepatic encephalopathy via induction of Nrf2/HO-1 and mitigation of NF-κB/MAPK signaling pathways | Litcius