TRIM7/RNF90 promotes autophagy via regulation of ATG7 ubiquitination during <i>L. monocytogenes</i> infection
Jie Wang, Xiao Qin, Yulu Huang, Qunmei Zhang, Jinyong Pei, Yì Wáng, Idan Goren, Shujun Ma, Zhishan Song, Yanzi Liu, Hongxia Xing, Hui Wang, Bo Yang
Abstract
; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MEF: mouse embryonic fibroblast; MOI: multiplicity of infection; PLA: proximity ligation assay; PMA: phorbol myristate acetate; PMA-THP1, PMA-differentiated THP1; PMs: peritoneal macrophages; PTMs: posttranslational modifications; STING1, stimulator of interferon response cGAMP interactor 1; TBK1, TANK binding kinase 1; TNF/TNF-α: tumor necrosis factor; TRIM7/RNF90: tripartite motif containing; Hainan Provincial Natural Science Foundation of China.
Topics & Concepts
AutophagyBiologyUbiquitinAutophagosomeUbiquitin ligaseCell biologyGene knockdownInnate immune systemIntracellularIntracellular parasiteMicrobiologyImmune systemImmunologyGeneBiochemistryApoptosisAutophagy in Disease and TherapyHIV Research and TreatmentPhagocytosis and Immune Regulation