Discovery of SP-96, the first non-ATP-competitive Aurora Kinase B inhibitor, for reduced myelosuppression
Naga Rajiv Lakkaniga, Lingtian Zhang, Binyam Belachew, Gunaganti Naresh, Brendan Frett, Hongyu Li
Topics & Concepts
ChemistryAurora B kinaseKinasePharmacophoreAurora inhibitorPotencyIC50SerinePharmacologyThreonineAurora kinaseNon-competitive inhibitionEnzymeTyrosine kinaseBiochemistryReceptorCellIn vitroBiologyCell cycleCell divisionSpindle apparatusMicrotubule and mitosis dynamicsCancer-related Molecular PathwaysNeuroblastoma Research and Treatments