Extracellular vesicles derived from M1 macrophages deliver miR-146a-5p and miR-146b-5p to suppress trophoblast migration and invasion by targeting TRAF6 in recurrent spontaneous abortion
Jinli Ding, Yan Zhang, Xiaopeng Cai, Yi Zhang, Sisi Yan, Jiayu Wang, Sainan Zhang, Tailang Yin, Chaogang Yang, Jing Yang
Abstract
Our findings indicate that miR-146a-5p and miR-146b-5p derived from EVs play important roles in intercellular communication between M1 macrophages and trophoblasts, illuminating a novel mechanism in M1 macrophage regulation of trophoblasts and their role in RSA.
Topics & Concepts
TrophoblastDeciduaExtracellular vesiclesCell biologyMicrovesiclesCell migrationImmune systemMacrophageImmunologyPathogenesisCellBiologyFetusMedicineCancer researchPregnancymicroRNAPlacentaIn vitroBiochemistryGeneGeneticsReproductive System and PregnancyPregnancy and preeclampsia studiesPreterm Birth and Chorioamnionitis