A Cross-Reactive Small Protein Binding Domain Provides a Model to Study Off-Tumor CAR-T Cell Toxicity
Joanne A. Hammill, Jacek M. Kwiecień, Anna Dvorkin‐Gheva, Vivian Wing Chong Lau, Christopher L. Baker, Ying Wu, Ksenia Bezverbnaya, Craig Aarts, Christopher W. Heslen, Galina Denisova, Heather Derocher, Katy Milne, Brad H. Nelson, Jonathan L. Bramson
Abstract
CAR-T cell product, indicating a role for additional variables. This work highlights the contributions of CAR-T cell-intrinsic variables to the pathogenesis of off-tumor toxicity.
Topics & Concepts
CD28Chimeric antigen receptorT cellPeripheral blood mononuclear cellToxicityCD8Cytokine release syndromeCytotoxic T cellAdoptive cell transferCancer researchCytokineT-cell receptorCellImmunologyMedicineAntigenPharmacologyBiologyChemistryImmune systemInternal medicineIn vitroBiochemistryCAR-T cell therapy researchNanowire Synthesis and ApplicationsAdvancements in Semiconductor Devices and Circuit Design