Impact of ComBat Harmonization on PET Radiomics-Based Tissue Classification: A Dual-Center PET/MRI and PET/CT Study
Doris Leithner, Heiko Schöder, Alexander Haug, Hebert Alberto Vargas, Peter Gibbs, Ida Häggström, Ivo Rausch, Michael Weber, Anton S. Becker, Jazmin Schwartz, Marius E. Mayerhoefer
Abstract
<b>Rationale:</b> To determine whether ComBat harmonization improves <sup>18</sup>F-FDG-PET radiomics-based tissue classification in pooled PET/MR and PET/CT datasets. <b>Methods:</b> Two-hundred patients who had undergone <sup>18</sup>F-FDG-PET/MR (two scanners/vendors; 50 patients each) or -PET/CT (two scanners/vendors; 50 patients each) were retrospectively included. Grey-level histogram (GLH), co-occurrence matrix (GLCM), run-length matrix (GLRLM), size-zone matrix (GLSZM), and neighborhood grey-tone difference matrix (NGTDM) radiomic features were calculated for volumes of interest in the disease-free liver, spleen, and bone marrow. For individual feature classes and a multi-class radiomic signature, tissue classification was performed on ComBat-harmonized and unharmonized pooled data, using a multi-layer perceptron neural network. <b>Results:</b> Median accuracies in training/validation datasets were: GLH, 69.5/68.3% (harmonized) vs. 59.5/58.9% (unharmonized); GLCM, 92.1/86.1% vs. 53.6/50.0%; GLRLM, 84.8/82.8% vs. 62.4/58.3%; GLSZM, 87.6/85.6% vs. 56.2/52.8%; NGTDM, 79.5/77.2% vs. 54.8/53.9%, and radiomic signature, 86.9/84.4% vs. 62.9/58.3%. <b>Conclusion:</b> ComBat harmonization may be useful for multi-center <sup>18</sup>F-FDG-PET radiomics studies using pooled PET/MR and PET/CT data.