Lenalidomide bypasses CD28 co-stimulation to reinstate PD-1 immunotherapy by activating Notch signaling
Chenlu Geng, Junyi Chen, Tianyu Song, Jae Hyung Jung, Min Long, Minfang Song, Tong Ji, Byung Soh Min, Jin Gu Lee, Bo Peng, Yi-Sheng Pu, Hongjie Fan, Piliang Hao, Qi Zhou, Eui‐Cheol Shin, Yong Cang
Topics & Concepts
LenalidomideCD28Cancer researchImmunotherapyT cellCD8Cytotoxic T cellCancer immunotherapyBiologyImmune systemPharmacologyMedicineImmunologyMultiple myelomaBiochemistryIn vitroProtein Degradation and InhibitorsCAR-T cell therapy researchUbiquitin and proteasome pathways