Combined p53- and PTEN-deficiency activates expression of mesenchyme homeobox 1 (MEOX1) required for growth of triple-negative breast cancer
Mari Gasparyan, Miao‐Chia Lo, Hui Jiang, Chang‐Ching Lin, Duxin Sun
Abstract
, but had no effect on the proliferation of luminal and HER2+ cancer cells and normal breast cells. RNA-Seq and immunoblotting analyses showed that MEOX1 knockdown decreased expression of tyrosine kinase 2 (TYK2), signal transducer and activator of transcription 5B (STAT5B), and STAT6 in p53- and PTEN-deficient TNBC cells. These results reveal the effects of combined p53- and PTEN-deficiency on MEOX1 expression and TNBC cell proliferation, suggesting that MEOX1 may serve as a potential therapeutic target for managing p53- and PTEN-deficient TNBC.
Topics & Concepts
PTENCancer researchGene knockdownTensinBiologyCell growthSignal transductionCell biologyPI3K/AKT/mTOR pathwayApoptosisGeneticsBiochemistryCancer-related Molecular PathwaysRNA modifications and cancerProtein Tyrosine Phosphatases