Pulmonary BCG induces lung-resident macrophage activation and confers long-term protection against tuberculosis
Elena Mata, Raquel Tarancón, Claudia Guerrero, Eduardo Moreo, Flavie Moreau, Santiago Uranga, Ana Belén Gómez, Dessislava Marinova, Mirian Domenech, Fernando González‐Camacho, Marta Monzón, Juan José Badiola, Jorge Domínguez‐Andrés, José Yuste, Alberto Anel, António Peixoto, Carlos Martı́n, Nacho Aguiló
Abstract
. BCG drove long-term activation of AMs, even after vaccine clearance, and these AMs reacted efficiently upon subsequent challenge. These results suggest the generation of a trained innate memory-like response in AMs induced by pulmonary BCG vaccination.
Topics & Concepts
MacrophageLungTuberculosisImmunologyMedicinePulmonary tuberculosisAlveolar macrophagePhagocytosisMicrobiologyBiologyPathologyInternal medicineIn vitroBiochemistryImmune responses and vaccinationsTuberculosis Research and EpidemiologyImmune cells in cancer