Copper exposure disrupts ovarian steroidogenesis in human ovarian granulosa cells via the FSHR/CYP19A1 pathway and alters methylation patterns on the SF-1 gene promoter
Yiqin Chen, Yan Sun, Pei‐Wen Wu, Yiwei Guo, Qi Wang, Qian Xu, Wang Panglin, Yan Sunjie, Wenxiang Wang
Topics & Concepts
Internal medicineEndocrinologyMethylationDNA methylationCopperFollicle-stimulating hormone receptorAromataseCholesterol side-chain cleavage enzymeGranulosa cellOvaryBiologyChemistryAndrologyGeneGene expressionHormoneMedicineFollicle-stimulating hormoneCytochrome P450Luteinizing hormoneMetabolismGeneticsCancerBreast cancerOrganic chemistryEffects and risks of endocrine disrupting chemicalsBirth, Development, and HealthReproductive System and Pregnancy