A minimal role for synonymous variation in human disease
Ryan S. Dhindsa, Quanli Wang, Dimitrios Vitsios, Oliver S. Burren, Fengyuan Hu, James E. DiCarlo, Leonid Kruglyak, Daniel G. MacArthur, Matthew E. Hurles, Slavé Petrovski
Topics & Concepts
Nonsynonymous substitutionSynonymous substitutionGeneticsBiologySilent mutationGeneMutationRNA splicingMutagenesisSequence (biology)Neutral theory of molecular evolutionGenomeMutation rateHuman genomeCodon usage biasRNAMissense mutationGenomics and Rare DiseasesGenomics and Phylogenetic StudiesCRISPR and Genetic Engineering