FGF/FGFR signaling pathway involved resistance in various cancer types
Yangyang Zhou, Cheng‐Yu Wu, Guangrong Lu, Zijing Hu, Qiuxiang Chen, Xiaojing Du
Abstract
Resistance becomes major clinical issue in cancer treatment, which strongly limits patients to benefit from oncotherapy. Growing evidences have been indicative of the critical role of fibroblast growth factor (FGF)/receptor (FGFR) signaling played in resistance to oncotherapy. In this review we discussed the underlying mechanisms of FGF/FGFR signaling mediated resistance to chemotherapy, radiotherapy and target therapy in various cancers. Meanwhile, we summarized the reported mechanism of FGF/FGFR inhibitors resistance in cancers.
Topics & Concepts
Fibroblast growth factor receptorFibroblast growth factorCancer researchMedicineCancerSignal transductionRadiation therapyChemotherapyMechanism (biology)ReceptorInternal medicineBiologyCell biologyPhilosophyEpistemologyFibroblast Growth Factor ResearchKruppel-like factors researchEpigenetics and DNA Methylation