Mutational spectrum and precision oncology for biliary tract carcinoma
Jianzhen Lin, Yinghao Cao, Xu Yang, Guangyu Li, Yang Shi, Dongxu Wang, Junyu Long, Yang Song, Jinzhu Mao, Fucun Xie, Yi Bai, Lei Zhang, Xiaobo Yang, Xueshuai Wan, Anqiang Wang, Mei Guan, Lin Zhao, Ke Hu, Jie Pan, Li Huo, Xin Lü, Yilei Mao, Xinting Sang, Henghui Zhang, Kai Wang, Xiaoyue Wang, Haitao Zhao
Abstract
Extensive genomic diversity and heterogeneity were observed among BTC patients, with contributions according to potential etiology exposures, anatomical subtypes and clinicopathological characteristics. We also demonstrated that patients with refractory BTCs who have PATs can derive considerable benefit from receiving a matched therapy, initiating further prospective clinical trials guided by molecular profiling among this aggressive cancer.
Topics & Concepts
KRASCDKN2AARID1AIntrahepatic CholangiocarcinomaMedicineInternal medicineOncologyDigital polymerase chain reactionCancerGallbladder cancerPTENPopulationEtiologyCancer researchMutationBiologyGeneGeneticsColorectal cancerApoptosisPolymerase chain reactionEnvironmental healthPI3K/AKT/mTOR pathwayCholangiocarcinoma and Gallbladder Cancer StudiesGenetic factors in colorectal cancer