Acute pharmacological degradation of Helios destabilizes regulatory T cells
Eric S. Wang, Alyssa L. Verano, Radosław P. Nowak, Jinghua Yuan, Katherine A. Donovan, Nicholas A. Eleuteri, Hong Yue, Kenneth Ngo, Patrick H. Lizotte, Prafulla C. Gokhale, Nathanael S. Gray, Eric S. Fischer
Topics & Concepts
Ubiquitin ligaseReprogrammingTranscription factorZinc fingerCell biologyUbiquitinCereblonUbiquitin-Protein LigasesChemistryBiologyCellBiochemistryGeneProtein Degradation and InhibitorsCAR-T cell therapy researchImmune Cell Function and Interaction