Near-infrared light-activated ROS generation using semiconducting polymer nanocatalysts for photodynamic–chemodynamic therapy
Yingyi Deng, Mengbin Ding, Liyun Zhu, Yijing Zhang, Fengshuo Wang, Lingzhou Zhao, Jingchao Li
Abstract
nanoparticles is greatly improved. As such, an amplified ROS level in tumor cells is obtained by PGFe to induce cell death. PGFe can be utilized to treat subcutaneous 4T1 tumors, observably inhibiting the tumor growth and suppressing lung and liver metastasis. This study thus provides a NIR light-activated ROS generation strategy for precise and effective treatments of tumors.
Topics & Concepts
Photodynamic therapySinglet oxygenNanocarriersPhotosensitizerReactive oxygen speciesPhotothermal therapyHydrogen peroxideTumor microenvironmentGlucose oxidaseMaterials scienceNanoparticleChemistryNanotechnologyCancer researchPhotochemistryOxygenMedicineTumor cellsBiochemistryBiosensorOrganic chemistryNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisPhotodynamic Therapy Research Studies