Intercellular transmission of cGAS-STING signaling in cancer
Qirou Wu, Xiaohong Leng, Pinglong Xu
Abstract
Cellular communication is necessary for organizing multicellular organisms, and is critical in tumorigenesis and progression. Immune and tumor cells use the cGAS-STING mechanism to sense and respond to genomic instability, DNA damage, and mitochondrial dysfunction induced by extra- and intracellular
Topics & Concepts
IntracellularMulticellular organismCarcinogenesisStingGenome instabilityCell biologyImmune systemMechanism (biology)BiologyDNA damageMitochondrionCancerDNAGeneGeneticsEpistemologyAerospace engineeringPhilosophyEngineeringinterferon and immune responsesViral Infections and VectorsMosquito-borne diseases and control