Litcius/Paper detail

NAC alleviative ferroptosis in diabetic nephropathy via maintaining mitochondrial redox homeostasis through activating SIRT3-SOD2/Gpx4 pathway

Quanwei Li, Jianzhao Liao, Weijin Chen, Kai Zhang, Hongji Li, Feiyang Ma, Hui Zhang, Qingyue Han, Jianying Guo, Ying Li, Lianmei Hu, Jiaqiang Pan, Zhaoxin Tang

2022Free Radical Biology and Medicine185 citationsDOI

Topics & Concepts

SOD2SIRT3GPX4MitochondrionChemistryDownregulation and upregulationGlutathioneOxidative stressDiabetic nephropathyMitochondrial ROSGPX1HomeostasisAcetylcysteinePharmacologyAntioxidantCell biologyDiabetes mellitusEndocrinologyBiochemistryBiologySuperoxide dismutaseAcetylationGlutathione peroxidaseEnzymeSirtuinGeneFerroptosis and cancer prognosisEpigenetics and DNA MethylationCancer-related molecular mechanisms research