Modulation of Lymphocyte Potassium Channel K<sub>V</sub>1.3 by Membrane-Penetrating, Joint-Targeting Immunomodulatory Plant Defensin
Seow Theng Ong, Saumya Bajaj, Mark R. Tanner, Shih Chieh Chang, Bankala Krishnarjuna, Xuan Rui Ng, Rodrigo A. V. Morales, Ming Wei Chen, Dahai Luo, Dharmeshkumar Patel, Sabina Yasmin, Jeremy Jun Heng Ng, Zhong Zhuang, Hai M. Nguyen, Abbas El Sahili, Julien Lescar, Rahul Patil, Susan A. Charman, Edward G. Robins, Julian Goggi, Peng Wen Tan, Pragalath Sadasivam, Boominathan Ramasamy, Siddana V. Hartimath, Vikas Dhawan, Janna Bednenko, Paul A. Colussi, Heike Wulff, Michael W. Pennington, Serdar Kuyucak, Raymond S. Norton, Christine Beeton, K. George Chandy
Abstract
dose. EgK5 shows promise for clinical development as a therapeutic for autoimmune diseases.
Topics & Concepts
Potassium channelEffectorArthritisChemistryCell biologyReceptorIn vivoAutoimmune diseasePeptideIon channelTransgeneAntigenAutoimmunityImmunologyBiologyBiophysicsImmune systemBiochemistryAntibodyGeneBiotechnologyToxin Mechanisms and ImmunotoxinsIon Channels and ReceptorsIon channel regulation and function