Age, COVID-19-like symptoms and SARS-CoV-2 seropositivity profiles after the first wave of the pandemic in France
Fabrice Carrat, Nathanaël Lapidus, Läétitia Ninove, Hélène Blanché, Delphine Rahib, Paola Mariela Saba Villarroel, Mathilde Touvier, Gianluca Severi, Marie Zins, Jean‐François Deleuze, Xavier de Lamballerie, for the SAPRIS-SERO study group, Fabrice Carrat, Pierre‐Yves Ancel, Marie-Aline Charles, Gianluca Severi, Mathilde Touvier, Marie Zins, Nathalie Bajos, Florence Jusot, Claude Martin, Laurence Meyer, Ariane Pailhé, Alexandra Rouquette, Alexis Spire, Sofiane Kab, Adeline Renuy, Stéphane Le-Got, Céline Ribet, Emmanuel Wiernik, Marcel Goldberg, Fanny Artaud, Pascale Gerbouin-Rérolle, Mélody Enguix, C Laplanche, Roselyn Gomes-Rima, Lyan Hoang, Emmanuelle Correia, Alpha Amadou Barry, Nadège Senina, Julien Allègre, Fabien Szabo de Edelenyi, Nathalie Druesne‐Pecollo, Younes Esseddik, Serge Herçberg, Valérie Benhammou, Anass Ritmi, Laetitia Marchand‐Martin, Cécile Zaros, Elodie Lordmi, Adriana Candea, Sophie de Visme, Thierry Siméon, Xavier Thierry, Bertrand Geay, Marie‐Noëlle Dufourg, Karen Milcent, Delphine Rahib, Nathalie Lydié, Clovis Lusivika‐Nzinga, Grégory Pannetier, Nathanael Lapidus, Isabelle Goderel, Céline Dorival, Jérôme Nicol, Cindy J. Lai, Liza Belhadji, Hélène Espérou, Sandrine Couffin-Cadièrgues, Jean‐Marie Gagliolo, Hélène Blanché, Jean-Marc Sébaoun, Jean-Christophe Beaudoin, Lætitia Gressin, Valérie Morel, Ouissam Ouili, Jean‐François Deleuze, Läétitia Ninove, Stéphane Priet, Paola Mariela Saba Villarroel, Toscane Fourié, Souand Mohamed Ali, Abdenour Amroun, Morgan Seston, Nazlı Ayhan, Boris Pastorino, Xavier de Lamballerie
Abstract
BACKGROUND: The interplay between age and symptoms intensity on antibody response to SARS-CoV-2 infection has not been studied in a general population setting. METHODS: We explored the serologic profile of anti-SARS-CoV-2 antibodies after the first wave of the pandemic, by assessing IgG against the spike protein (ELISA-S), IgG against the nucleocapsid protein (ELISA-NP) and neutralizing antibodies (SN) in 82,126 adults from a French population-based multi-cohort study. RESULTS: ELISA-S positivity was increased in 30- to 49-year-old adults (8.5%) compared to other age groups (5.6% in 20- to 29-year-olds, 2.8% in ≥ 50-year-olds). In the 3681 ELISA-S positive participants, ELISA-NP and SN positivity exhibited a U-shaped relationship with age, with a lower rate in 30- to 49-year-old adults, and was strongly associated with COVID-19-like symptoms. CONCLUSION: Our study confirms the independent role of age and symptoms on the serologic profile of anti-SARS-CoV-2 antibodies, but the non-linear relationship with age deserves further investigation.